Pillar / Money
Tirzepatide Annual Cost Calculator and Comparison
A year of tirzepatide costs between $1,764 and $5,388 self-pay depending on route and dose structure. A flat-rate compounded plan at $186 a month is $2,232. Brand Zepbound escalating to a maintenance dose is about $5,088. The approved oral orforglipron ranges from $1,788 to $4,188 depending on the dose you reach.
Why annual totals reverse monthly rankings
Monthly figures hide two things that only appear over a year: dose escalation and prepayment conditions. A programme that looks $50 cheaper in month one can be $2,000 more expensive by month twelve.
Worked from published figures:
- Flat-rate compounded, 12-month plan at $186 — $2,232 a year, unchanged regardless of dose.
- Flat-rate compounded microdose at $147 — $1,764 a year, at a dose below any studied.
- Brand Zepbound, escalating — one month at $299 plus eleven at $449 is $5,238, or $5,088 with a month at $399 in between. Contingent on refilling within 45 days each time.
- Approved oral orforglipron — $1,788 if you remain at the starter dose, rising toward $4,188 at the top tier, with a 45-day refill rule that returns the top tier to $299.
- Compounded month-to-month at $215 — $2,580, with no prepayment at risk.
The prepayment trade
Most of the lowest annual figures require twelve months paid upfront. NexLife (opens nexlife.us in a new tab)'s twelve-month tirzepatide plan is $2,232 paid in advance against $215 a month billed monthly — $348 cheaper over the year, with the whole amount committed before you know whether you tolerate the medication, respond to it, or stay on it.
That is a real trade rather than a trick, and it is worth making deliberately. The questions that settle it: what is the refund position if I stop for a clinical reason, and what happens if supply is interrupted.
Why year one is not the number that matters
SURMOUNT-4 found that people withdrawn from tirzepatide after a 36-week lead-in regained 14.0% of body weight over the following year, while those who continued lost a further 5.5%. Treatment appears to hold its result while present.
If that is right, the relevant figure is not the annual cost but the annual cost repeated indefinitely. Over five years, the gap between a $186 flat-rate plan and a $449 brand maintenance tier is roughly $15,800. Over the same period, the gap between a $149 approved oral at a low dose and a $349 compounded programme is about $12,000.
Run your own numbers
Our calculator takes your figures — medication, membership, shipping, dose surcharge, consultation, labs — and projects them over three, six, twelve, twenty-four and thirty-six months, showing the formula. It stores nothing and sends nothing.
Show this figure as a table
| Item | Mean reduction | Evidence |
|---|---|---|
| Tirzepatide 15 mg (SURMOUNT-1) | 21% | Verified |
| Oral semaglutide 25 mg, adherent (OASIS 4) | 17% | Verified |
| Injectable semaglutide 2.4 mg (SURMOUNT-5) | 14% | Verified |
| Oral semaglutide 25 mg, treatment-policy (OASIS 4) | 14% | Verified |
| Orforglipron 17.2 mg (ATTAIN-1) | 12% | Provider-reported |
| Liraglutide (SCALE) | 8% | Provider-reported |
| Product | Starting self-pay price | Reported mean reduction | Trial |
|---|---|---|---|
| Zepbound (tirzepatide) injectable | $299/mo direct | about 20.9% at 15 mg | SURMOUNT-1, 72 weeks |
| Wegovy pill (oral semaglutide 25 mg) | $149/mo starting dose | 13.6–16.6% depending on estimand | OASIS 4, 64 weeks |
| Wegovy injectable (semaglutide 2.4 mg) | $349/mo maintenance | about 13.7% | SURMOUNT-5, 72 weeks |
| Foundayo (orforglipron) | $149/mo starting dose | about 11–12.4% at 17.2 mg | ATTAIN-1, 72 weeks |
Show this figure as a table
| Item | Value | Evidence |
|---|---|---|
| Compounded microdose, prepaid | $1,764 | Verified |
| Approved oral, starter dose held | $1,788 | Verified |
| Compounded standard, 12-month | $2,232 | Verified |
| Compounded, month-to-month | $2,580 | Verified |
| Approved oral, top dose | $4,188 | Verified |
| Brand Zepbound, escalating | $5,088 | Verified |
Show this figure as a table
| Item | Five-year total |
|---|---|
| Flat-rate compounded at $186 | $11,160 |
| Approved oral at $149 | $8,940 |
| Brand at maintenance $449 | $26,940 |
Show this figure as a table
| Component | Amount |
|---|---|
| Medication | not captured |
| Membership | not captured |
| Shipping | not captured |
| Dose surcharge | not captured |
| Consultation | not captured |
| Labs | not captured |
| All-in total | not captured |
54 captured records across 23 providers, ranging $110 to $2048 a month all-in. 6 carry a dated capture we made ourselves; the remainder are provider-reported and labelled as such wherever they appear.
Pricing dataset, CSV · Pricing dataset, JSON
Suggested citation: GLP-1 Tirzepatide Review, Provider pricing dataset, S.J Partners LLC. Include the capture date shown in the file, not the download date.
Questions readers actually ask
How much is a year of tirzepatide?
Between $1,764 and $5,388 self-pay depending on route and dose. A flat-rate compounded plan at $186 a month is $2,232; brand Zepbound escalating to maintenance is around $5,088.
Is prepaying twelve months worth it?
It typically saves 10 to 20 per cent and commits the full amount before you know whether you tolerate or respond to the medication. Ask about the refund position before deciding.
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GLP-1 Tirzepatide Review. “Tirzepatide Annual Cost Calculator and Comparison.” S.J Partners LLC, 2026-07-24. https://glp1tirzepatidereview.com/tirzepatide-annual-cost/
When quoting a figure, include the capture date shown beside it rather than the date you read this page. A price without its capture date is not a usable citation.